A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor
A. Inoue, L. J. Janke, B. L. Gudenas, H. Jin, Y. Fan, J. Pare, M. R. Clay, P. A. Northcott, A. C. Hirbe, X. Cao
This paper develops a genetic mouse model of MPNST that closely mimics human tumors in genetics, histology, and transcriptome.
bioRxiv · May 3, 2021Cancer Biology