Author

A. C. Hirbe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. A. Pratilas· 2 shared D. A. Largaespada· 2 shared D. K. Wood· 2 shared E. Conniff· 2 shared J. C. Pino· 2 shared K. Pollard· 2 shared S. J. Gosline· 2 shared Y. Lyu· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

C. A. Pratilas

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Author profile →

4 papers

Recent·Most cited

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

J. Wang, A. Calizo, L. Zhang, J. C. Pino, Y. Lyu, K. Pollard, X. Zhang, A. T. Larsson, E. Conniff, N. Llosa, D. K. Wood, D. A. Largaespada, S. E. Moody, S. J. Gosline, A. C. Hirbe, C. A. Pratilas

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

bioRxiv · Feb 2, 2023Cancer Biology

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA

I. Cortes-Ciriano, C. D. Steele, K. G. Piculell, A. Al-Ibraheemi, V. Eulo, M. M. Bui, A. Chatzipli, B. C. Dickson, D. C. Borcherding, A. Feber, A. Galor, J. Hart, K. B. Jones, J. T. Jordan, R. H. Kim, , D. T. Miller

This study identifies genomic patterns in MPNST evolution linked to clinical outcomes and shows these patterns are detectable in cell-free DNA.

bioRxiv · May 3, 2022 · PreprintCancer Biology

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

H. Bhatia^, A. T. Larsson^, A. Calizo^, K. Pollard, X. Zhang, E. Conniff, J. F. Tibbitts, S. H. Osum, K. B. Williams, A. L. Crampton, T. Jubenville, D. Schefer, K. Yang, Y. Lyu, J. Bade, , A. C. Hirbe

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology

A genetic mouse model with postnatal Nf1 and p53 loss recapitulates the histology and transcriptome of human malignant peripheral nerve sheath tumor

A. Inoue, L. J. Janke, B. L. Gudenas, H. Jin, Y. Fan, J. Pare, M. R. Clay, P. A. Northcott, A. C. Hirbe, X. Cao

This paper develops a genetic mouse model of MPNST that closely mimics human tumors in genetics, histology, and transcriptome.

bioRxiv · May 3, 2021Cancer Biology