Regulation of the mammalian-brain V-ATPase via ultra-slow mode-switching
E. KOSMIDIS, C. G. Shuttle, J. Preobraschenski, M. Ganzella, P. J. Johnson, S. Veshaguri, M. P. Moeller, O. Marantos, J. L. Pedersen, R. Jahn, D. Stamou
This study shows mammalian-brain V-ATPases switch between proton-pumping, inactive, and proton-leaky modes, with ATP regulating mode-switching probability rather than pumping rate.
bioRxiv · Oct 6, 2022 · PreprintBiophysics