Author

J. R. Braxton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:statistical model· 1

Frequent Co-Authors

D. R. Southworth· 2 shared E. Tse· 2 shared A. C. Thwin· 1 shared C. R. Altobelli· 1 shared H. Shao· 1 shared J. E. Gestwicki· 1 shared M. R. Arkin· 1 shared M. R. Tucker· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

D. R. Southworth

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2 papers

Recent·Most cited

The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

J. R. Braxton, C. R. Altobelli, M. R. Tucker, E. Tse, A. C. Thwin, M. R. Arkin, D. R. Southworth

This study identifies UBXD1 as a p97 ATPase inhibitor and shows how its domains induce structural remodeling and ring opening of the p97 hexamer.

bioRxiv · May 15, 2023 · PreprintBiochemistry

Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly

J. R. Braxton, H. Shao, E. Tse, J. E. Gestwicki, D. R. Southworth

The paper determines cryo-EM structures of a mtHsp60 mutant to show how apical domains coordinate client engagement and chaperonin assembly during the ATP-dependent cycle.

bioRxiv · May 15, 2023Biochemistry