Author

C. R. Altobelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Thwin· 1 shared C. A. Berdan· 1 shared D. K. Nomura· 1 shared D. R. Southworth· 1 shared E. Tse· 1 shared H. S. Lehtola· 1 shared J. A. Olzmann· 1 shared J. R. Braxton· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. C. Thwin

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2 papers

Recent·Most cited

The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

J. R. Braxton, C. R. Altobelli, M. R. Tucker, E. Tse, A. C. Thwin, M. R. Arkin, D. R. Southworth

This study identifies UBXD1 as a p97 ATPase inhibitor and shows how its domains induce structural remodeling and ring opening of the p97 hexamer.

bioRxiv · May 15, 2023 · PreprintBiochemistry

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells

C. A. Berdan, R. Ho, H. S. Lehtola, M. To, X. Hu, T. R. Huffman, Y. Petri, C. R. Altobelli, S. G. Demeulenaere, J. A. Olzmann, T. J. Maimone, D. K. Nomura

This study identifies parthenolide's covalent targeting of FAK1 in breast cancer cells, showing inhibition of FAK1-dependent pathways and cancer cell proliferation.

bioRxiv · Feb 15, 2019Cancer Biology