Author

J. R. Buchan

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. T. Byrd· 1 shared L. Marmorale· 1 shared S. Marcinowski· 1 shared V. Addison· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperCell Biology

A. T. Byrd

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1 paper

Recent·Most cited

Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism

A. T. Byrd, L. Marmorale, V. Addison, S. Marcinowski, J. R. Buchan

This study identifies ESCRT and Rsp5/NEDD4 as regulators of TDP-43 clearance via endolysosomal pathways, showing their role in reducing TDP-43 toxicity in ALS models.

bioRxiv · Dec 5, 2022Cell Biology