Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex
J. Ramirez-Franco, F. Azzaz, M. Sangiardi, G. Ferracci, F. Youssouf, M. R. Popoff, M. Seagar, C. Leveque, J. Fantini, O. EL FAR
This study presents a model of BoNT/B binding to a synaptotagmin/ganglioside complex in a membrane topology, revealing interactions and reduced sensitivity in Felidae with a synaptotagmin2 variant.
bioRxiv · Oct 18, 2021 · PreprintPharmacology & Toxicology