Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin (ELGA) reveal functional IP3 receptors
B. Calvo, P. Torres-Vidal, A. Delrio, C. Rodriguez, F. Aulestia, J. Rojo-Ruiz, B. M. McVeigh, V. Moiseenkova-Bell, D. I. Yule, J. Garcia-Sancho, S. Patel, M. T. Alonso
The paper uses a modified aequorin probe to measure Ca2+ in endo-lysosomes, revealing IP3-sensitive Ca2+ stores and functional IP3 receptors in this compartment.
bioRxiv · Jul 11, 2023 · PreprintPhysiology