Author

D. I. Yule

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 8 Cell Biology· 5 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 13 Approach:experimental assay· 13 Assay:imaging· 6 Organism:mouse· 6 Research Focus:cell type annotation· 5 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

V. Arige· 6 shared L. E. Wagner· 5 shared J. Sneyd· 4 shared L. E. Terry· 4 shared M. Trebak· 3 shared G. Fan· 2 shared G.-Y. Son· 2 shared I. I. Serysheva· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersPhysiology

V. Arige

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjogrens syndrome

K.-T. Huang, L. E. Wagner, T. Takano, X.-X. Lin, H. Bagavant, U. Deshmukh, D. I. Yule

This study identifies dysregulated Ca2+ signaling and mitochondrial dysfunction in a mouse model of early Sjogrens syndrome, leading to reduced fluid secretion.

bioRxiv · Mar 19, 2024Physiology

Loss of STIM1 and STIM2 in salivary glands disrupts ANO1 function but does not induce Sjogren's disease

G.-Y. Son, A. Zou, A. Wahl, K. T. Huang, M. Vinu, S. Zorgit, F. Zhou, L. Wagner, Y. Idaghdour, D. I. Yule, S. Feske, R. S. Lacruz

This study shows that loss of STIM1 and STIM2 in salivary glands reduces ANO1 function and saliva production but does not cause Sjogren's disease, suggesting a link between SOCE and TLR8 signaling.

bioRxiv · Jan 8, 2024Physiology

A PACAP-activated network for secretion requires coordination of calcium influx and calcium mobilization

X. Chen, N. A. Bell, B. L. Coffman, A. Rabino, R. Garcia-Mata, D. I. Yule, D. Axelrod, A. Smrcka, D. R. Giovannucci, A. Anantharam

The paper shows PACAP induces sustained Ca2+ increases in chromaffin cells by coupling Ca2+ influx and mobilization via PLCε activity.

bioRxiv · Jan 3, 2024Cell Biology

Architecture of Ca2+ tunneling, a basic Ca2+ signaling modality important for secretion

R. Courjaret, L. E. Wagner, R. R. Ammouri, L. Assaf, F. Yu, M. Fisher, M. Terasaki, D. I. Yule, K. Machaca

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

bioRxiv · Dec 17, 2023 · PreprintCell Biology

Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin (ELGA) reveal functional IP3 receptors

B. Calvo, P. Torres-Vidal, A. Delrio, C. Rodriguez, F. Aulestia, J. Rojo-Ruiz, B. M. McVeigh, V. Moiseenkova-Bell, D. I. Yule, J. Garcia-Sancho, S. Patel, M. T. Alonso

The paper uses a modified aequorin probe to measure Ca2+ in endo-lysosomes, revealing IP3-sensitive Ca2+ stores and functional IP3 receptors in this compartment.

bioRxiv · Jul 11, 2023 · PreprintPhysiology

Tools for Quantitative Analysis of Calcium Signaling Data Using Jupyter-Lab Notebooks

J. Rugis, J. Chaffer, J. Sneyd, D. I. Yule

The paper presents a method for analyzing calcium signaling data using Jupyter-Lab notebooks with custom scripts to manage complexity and improve workflow efficiency.

bioRxiv · Jun 13, 2023 · PreprintCell Biology

Structural dynamics underlying gating and regulation in IP3R channel

G. Fan, M. R. Baker, L. E. Terry, V. Arige, M. Chen, A. Seryshev, M. L. Baker, S. J. Ludtke, D. I. Yule, I. I. Serysheva

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

bioRxiv · May 27, 2022Biophysics

Regulation of Store-Operated Ca2+ Entry by IP3 Receptors Independent of Their Ability to Release Ca2+

P. Chakraborty, B. K. Deb, V. Arige, T. Musthafa, S. Malik, D. I. Yule, C. W. Taylor, G. Hasan

The paper shows IP3Rs regulate neuronal SOCE through IP3 binding, independent of Ca2+ release, by enhancing STIM1-Orai1 association.

bioRxiv · Apr 12, 2022Cell Biology

Functional Determination of Calcium Binding Sites Required for the Activation of Inositol 1,4,5-trisphosphate receptors.

V. Arige, L. E. Terry, L. E. Wagner, M. R. Baker, G. Fan, I. I. Serysheva, D. I. Yule

This study identifies acidic residues in IP3Rs critical for Ca2+ binding and activation, showing their role in modulating channel activity and Ca2+ sensitivity.

bioRxiv · Mar 7, 2022Physiology

Functional Communication between IP3R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE

M. Ahmad, H. L. Ong, H. Saadi, G.-Y. Son, Z. Shokatian, L. E. Terry, M. Trebak, D. I. Yule, I. Ambudkar

This study identifies IP3R-mediated local [Ca2+]ER decreases as the driver of immobile STIM2 clusters at ER-PM junctions, marking a checkpoint for SOCE initiation under sub-threshold stimuli.

bioRxiv · Sep 24, 2021 · PreprintPhysiology

CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors

V. Arige, L. E. Terry, T. R. Knebel, L. E. Wagner, D. I. Yule

This study shows that CREB regulates IP3R1 expression and localization, affecting Ca2+ release and puffs.

bioRxiv · May 5, 2021Physiology

Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter

R. E. Yoast, S. M. Emrich, X. Zhang, P. Xin, V. Arige, T. Pathak, J. C. Benson, M. T. Johnson, N. Lakomski, N. Hempel, J. M. Han, G. Dupont, D. I. Yule, J. Sneyd, M. Trebak

This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.

bioRxiv · Apr 7, 2021Cell Biology

The characteristics of intracellular Ca2+ signals in vivo necessitate a new model for salivary fluid secretion

D. I. Yule, T. Takano, A. M. Wahl, K. T. Huang, J. Rugis, J. Sneyd

The study observes localized Ca2+ signals in live mice that contradict previous in vitro models of salivary secretion and proposes a new mathematical model to explain the mechanism.

bioRxiv · Dec 30, 2020 · PreprintPhysiology

Omnitemporal choreographies of IP3R and all five STIM/Orai underlie the complexity of mammalian Ca2+ signaling

S. M. Emrich, R. E. Yoast, P. Xin, V. Arige, L. E. Wagner, N. Hempel, D. L. Gill, J. Sneyd, D. I. Yule, M. Trebak

This paper shows that all five STIM1/2 and Orai1/2/3 isoforms, along with IP3R, work together in a graded manner to ensure precise and diverse Ca2+ signaling in mammals.

bioRxiv · Oct 4, 2020Physiology