Revisiting the bad luck hypothesis: Cancer risk and aging are linked to replication-driven changes to the epigenome
C. J. Minteer, K. Thrush, P. Niimi, J. Rozowsky, J. Liu, M. Frank, T. McCabe, E. Hofstatter, M. Rozenblit, L. Pusztai, K. Beckman, M. Gerstein, M. E. Levine
The paper shows that aging and cancer share an epigenetic replication signature linked to DNA methylation, which increases with age and correlates with cancer risk.
bioRxiv · Sep 14, 2022 · PreprintCancer Biology