M. Frank

Oddball evoked deviant responses reflect complex context dependent expectations in mouse V1

This study investigates how deviant responses in mouse V1 are influenced by temporal context and expectation, showing they reflect complex, experience-dependent mechanisms rather than simple adaptation.

Leveraging a large language model to predict protein phase transition: a physical, multiscale and interpretable approach

This paper fine-tunes a large language model to predict protein phase transitions from sequence data and shows its utility in assessing sequence variants' effects on aggregation and droplet formation.

Sialoglycan binding triggers spike opening in a human coronavirus

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

Single-cell analysis maps distinct cellular responses to rhizobia and identifies the novel infection regulator SYMRKL1 in Lotus japonicus

Integrated PET and confocal imaging informs a functional timeline for the dynamic process of vascular reconnection during grafting.

This paper uses integrated PET and confocal imaging to establish a spatiotemporal timeline for vascular reconnection during grafting in tomato.

Chromosome-level genome assembly of Euphorbia peplus, a model system for plant latex, reveals that relative lack of Ty3 transposons contributed to its small genome size

This paper presents a chromosome-level genome assembly of Euphorbia peplus, identifies a gene cluster for ingenol mebutate biosynthesis, and explains its small genome size through restricted Ty3 transposon expansion.

Revisiting the bad luck hypothesis: Cancer risk and aging are linked to replication-driven changes to the epigenome

The paper shows that aging and cancer share an epigenetic replication signature linked to DNA methylation, which increases with age and correlates with cancer risk.

CEP peptide and cytokinin pathways converge on CEPD glutaredoxins to inhibit root growth

This study shows that CEP and cytokinin pathways intersect by converging on CEPD glutaredoxins to inhibit root growth.

Anatomical and biophysical characterization of intergeneric graft-incompatibility within the Solanoideae

This study investigates graft compatibility between four Solanoideae species, finding that only tomato and eggplant heterografts are fully compatible, while others show delayed incompatibility.

Isoform-specific O-glycosylation dictates Ebola virus infectivity

This study shows that specific O-glycosylation of Ebola virus glycoprotein affects viral infectivity and identifies key host enzymes involved in this process.

The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

The paper identifies a conserved free fatty acid-binding pocket in pathogenic β-coronavirus spike proteins that suppresses viral infection and replication.

A bacterial pan-genome makes gene essentiality strain-dependent and evolvable

The paper investigates how a bacterial pan-genome affects gene essentiality and shows that essential genes can evolve to become non-essential through genetic changes and mechanisms like functional redundancy and pathway rewiring.

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

This study creates a genome-wide atlas of antibiotic susceptibility targets in Streptococcus pneumoniae, identifying a 'tolerome' that influences resistance and highlights its evolutionary significance.

The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway

This study identifies Beauvericin as an activator of dendritic cells via the TLR4 signaling pathway, suggesting its potential as a vaccine adjuvant or cancer immunotherapy.

Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers

The paper investigates human-specific CD33 mutations linked to cognitive protection and Alzheimer's disease resistance, linking them to evolutionary pressures and immune evasion.

The Evolutionary History of Small RNAs in the Solanaceae

The paper uses over 255 small RNA datasets to characterize the small RNA landscape across the Solanaceae family, revealing dynamic evolutionary patterns and genus-specific similarities.

Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies

This study uses molecular dynamics simulations to analyze SARS-CoV-2 spike protein interactions with antibodies, revealing structural dynamics and mutation impacts on neutralization.

The transcriptomic landscape of the photoperiodic stress response in Arabidopsis thaliana resembles the response to pathogen infection.

The paper identifies transcriptomic changes in Arabidopsis thaliana under photoperiod stress that resemble pathogen defense responses and prime resistance to subsequent infection.

Site-specific steric control of SARS-CoV-2 spike glycosylation

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

Gene regulatory networks for compatible versus incompatible grafts identify a role for SlWOX4 during junction formation

The paper identifies SlWOX4 as a key regulator in tomato grafting by comparing gene regulatory networks of compatible and incompatible grafts.

Quantitative dissection of color patterning in the foliar ornamental Coleus reveals underlying features driving aesthetic value

This study uses a new phenotyping approach to analyze color patterns in coleus plants and identifies features driving breeder and consumer preferences.

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

Structure, Dynamics, Receptor Binding, and Antibody Binding of Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane

This study uses molecular dynamics simulations to analyze the structure, dynamics, and antibody binding of the fully-glycosylated SARS-CoV-2 spike protein, revealing key roles of glycans in stabilizing RBD conformations and antibody epitope exposure.

Vein-to-blade ratio is an allometric indicator of climate-induced changes in grapevine leaf size and shape

The paper uses vein-to-blade area ratio as an allometric indicator to show climate impacts on grapevine leaf size and shape across multiple growing seasons.

Root-derived trans-zeatin cytokinin protects Arabidopsis plants against photoperiod stress

This study identifies root-derived trans-zeatin cytokinins as protective against photoperiod stress in Arabidopsis by acting through a two-component signaling system.

Acclimation, priming and memory in the response of Arabidopsis thaliana seedlings to cold stress

This study investigates how Arabidopsis thaliana seedlings respond to cold stress through acclimation, priming, and memory, finding that freezing tolerance increases with cold exposure and memory is lost once tolerance reaches naive levels.

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

Persistent homology demarcates a leaf morphospace

This paper uses persistent homology to analyze leaf shapes from 182,707 leaves across 141 plant families, revealing phylogenetic and geographic differences in leaf morphology.