Specificity and promiscuity of JAK recruitment regulates pleiotropy of cytokine-receptor signaling
E. Zoler, T. Meyer, J. S. Bellon, B. Sun, J. Piehler, G. Schreiber
The paper investigates JAK recruitment specificity and promiscuity in cytokine-receptor signaling, finding that JAKs can interchangeably bind to receptors, leading to cell type-specific signaling pleiotropy.
bioRxiv · Oct 4, 2023Biochemistry