Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine
K. Singh, E. Y. Faraoni, Y. Dai, V. Chandra, E. Vucic, T. Mills, M. Pruski, T. Clark, G. Van Buren, N. C. Thosani, J. S. Bynon, C. J. Wray, D. Bar-Sagi, K. L. Poulsen, L. A. Vornik, , J. Bailey Lundberg
This study identifies CD73 as a key driver of immunosuppression in pancreatic ductal adenocarcinoma, showing its role in adenosine generation and tumor progression.
bioRxiv · Nov 29, 2021 · PreprintCancer Biology