Y. Dai

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

The paper identifies FLVCR1b as the mitochondrial heme exporter that delivers heme to GAPDH and downstream hemeproteins in human cells.

Pseudovibriamides from Pseudovibrio marine sponge bacteria promote swarming motility via transcriptional modulation

This paper identifies pseudovibriamides A and B as bacterial signaling molecules that modulate transcription and affect motility in Pseudovibrio brasiliensis.

Single-cell multiomics reveals a gene regulatory circuit promoting leukemia cell differentiation

This study uses single-cell multiomics to identify a gene regulatory circuit involving SPI1 and CEBPE that promotes differentiation in APL leukemia cells under ATRA treatment.

The 3D ultrastructural morphology of a marine ammonia-oxidizing archaeon

This study uses cryo-ET and STEM-EDS to reveal the ultrastructural morphology and elemental composition of Nitrosopumilus maritimus SCM1, identifying two types of storage granules.

Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

Chaperone-mediated autophagy is an overlooked pathway for mutant alpha-1 antitrypsin Z degradation

This study identifies chaperone-mediated autophagy (CMA) as a key pathway for degrading mutant alpha-1 antitrypsin Z (ATZ), showing that enhancing CMA reduces ATZ accumulation in AATD.

Global control of cellular physiology by biomolecular condensates through modulation of electrochemical equilibria

This study shows that biomolecular condensates modulate electrochemical gradients in cells, affecting gene expression, membrane potential, and bacterial survival under antibiotic stress.

Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositis

The paper uses single-cell RNA sequencing to identify molecular pathways and immune subsets in immune-related myocarditis and myositis, finding clonally expanded CD8+ T cells and specific myeloid cell populations associated with adverse outcomes.

SenePy: Unveiling the Cell-Type Specific Landscape of Cellular Senescence through Single-Cell Analysis in Living Organisms

SenePy identifies cell-type specific senescence signatures from single-cell data, improving senescent cell detection in vivo and revealing increased senescence in diseases like COVID-19 and myocardial infarction.

Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination

This study tracks memory T follicular helper cells and antibody response after three doses of CoronaVac vaccine over 300 days, showing increased neutralizing antibodies and cTFH cells, with correlation between cTFH and antibody titers.

Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy in triple negative breast cancer

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

Dominant Role of Stochastic Processes in Soil Fungal Communities in Pioneer Forests at a Regional Scale

This study shows that stochastic processes dominate soil fungal community assembly in Populus davidiana forests, with elevation having a greater impact than seasonality.

Preclinical Basis of the Efficacy and Pharmacodynamics of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody with Potent Implications for Clinical Benefit

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance in a p53-dependent manner

This study shows that pancreatic cancer organoids adapt to acidic environments, increasing drug resistance, and this effect is p53-dependent.

Cryo-EM Structure of the 50S-HflX Complex Reveals a Novel Mechanism of Antibiotic Resistance in E. coli

The paper presents a cryo-EM structure of the E. coli 50S-HflX complex, revealing how HflX interacts with the ribosome and contributes to antibiotic resistance by displacing antibiotics from the peptidyl transferase center.

O-GlcNAcylation promotes YTHDF1 cytosolic localization and colorectal cancer tumorigenesis

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

Structural and Functional Insights into the Action Mode of A Mitochondrial AAA+ Disaggregase CLPB

The paper was withdrawn due to duplicate posting and is no longer available for citation.

Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

The paper maps lymphocyte interactions in lung adenocarcinoma using spatial analysis and machine learning, revealing dynamic lymphocyte networks that support anti-tumor immune responses.

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

This paper develops an integrated electrochemical liquid biopsy platform for detecting cancer exosomes from blood using a rational engineering strategy.

Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine

This study identifies CD73 as a key driver of immunosuppression in pancreatic ductal adenocarcinoma, showing its role in adenosine generation and tumor progression.

Oxalic acid binds to gustatory receptor Gr23a and inhibits feeding in the brown planthopper

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

A new class of cell wall-recycling L,D-carboxypeptidase determines β-lactam susceptibility and morphogenesis in Acinetobacter baumannii

This paper identifies ElsL as a novel L,D-carboxypeptidase in A. baumannii essential for cell wall recycling, antibiotic resistance, and morphogenesis.

Gestational insulin resistance is mediated by the gut microbiome-indoleamine 2,3-dioxygenase axis

This study identifies the gut microbiome-indoleamine 2,3-dioxygenase (IDO1) axis as a mediator of gestational insulin resistance in mice.

REAP: A platform to identify autoantibodies that target the human exoproteome

REAP identifies autoantibodies targeting the human exoproteome by screening patient samples against a yeast-displayed extracellular protein library, revealing known and novel reactivities in autoimmune diseases.

Infection and chronic disease activate a brain-muscle signaling axis that regulates muscle performance

This study identifies a brain-muscle signaling axis activated by infections and chronic diseases that reduces muscle performance through cytokine-dependent mechanisms.

A novel family of nonribosomal peptides modulate collective behavior in Pseudovibrio bacteria isolated from marine sponges

This study identifies a novel family of nonribosomal peptides, pseudovibriamides, produced by Pseudovibrio bacteria that modulate motility and biofilm formation, distinct from known surfactant lipopeptides.

Characterization and description of Faecalibacterium butyricigenerans sp. nov. and F. longum sp. nov., isolated from human faeces

This paper describes two new species of Faecalibacterium isolated from human feces, supported by phylogenetic, genomic, and phenotypic analyses.

Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy

This study shows that MFN1-mediated mitochondrial fusion enhances ATP production, which supports autophagy and macrophage mycobactericidal activity against Mtb.

Taxonomic description and genome sequence of Christensenella intestinihominis sp. nov., a novel cholesterol-lowering bacterium isolated from human gut

This paper describes a new bacterial species, Christensenella intestinihominis, isolated from the human gut, and reports its cholesterol-lowering ability and exopolysaccharide production.