Cell-associated, Heparin-like Molecules Modulate the Ability of LDL to Regulate PCSK9 Uptake
This study shows LDL inhibits PCSK9 binding to LDLR via heparan sulfate proteoglycans, with the full PCSK9 prodomain required for this interaction and the S127R variant having increased heparin-like molecule affinity.
bioRxiv · May 23, 2018Biochemistry