J. S. G. Slusky

This study experimentally validates a novel evolutionary mechanism where an extracellular loop converts to a transmembrane β-hairpin, increasing β-barrel strand number and pore size in membrane proteins.

This study shows that detergent headgroup composition affects TolC folding in vitro, with nonionic detergents promoting functional trimer formation while zwitterionic detergents induce non-native folds.

This paper reports the first structure of colicin E1 bound to TolC, showing how it opens its hinge to plug the channel and inhibit antibiotic efflux.

The paper develops a machine learning model to classify enzymatic and non-enzymatic metal sites in proteins with high precision and recall, identifying key physicochemical features.

The paper compares membrane and soluble beta-barrels to find differences in size, shape, and hydrophobicity, revealing membrane barrels are taller, wider, and have more regular alternation.

This study investigates how different extracellular loop types affect the slow folding rate of OmpA, finding that hydrogen bond levels in loops influence this rate.

This study develops a concentration-dependent refolding protocol for outer-membrane efflux pump proteins, enabling high-yield preparation and structural analysis.

The paper examines the evolutionary convergence of efflux pump beta-barrel folds in Gram-negative bacteria by analyzing structural and sequence data.