J. S. Logue

The amoeboid migration of monocytes in confining channels requires the local remodeling of the cortical actin cytoskeleton by cofilin-1

This study shows that monocytes use an amoeboid migration mode in confining channels, driven by cofilin-1-mediated actin remodeling and myosin contractility at the cell rear.

The activation of INF2 by Piezo1/Ca2+ is required for mesenchymal to amoeboid transition in confined environments

The paper shows that Piezo1/Ca2+ activates INF2 to drive mesenchymal to amoeboid transition in melanoma cells under confinement.

A novel Fiji/ImageJ plugin for the rapid analysis of blebbing cells

The paper introduces a Fiji/ImageJ plugin, Analyze_Blebs, for analyzing cell migration and morphometrics in fast amoeboid cells, showing it detects differences in bleb size and correlates cell stiffness with migration.

Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels

This study shows melanoma cells use both mesenchymal and bleb-based migration in 3D narrow channels, with blebbing cells being faster when adhesion is absent.

ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

This study shows that ADF and cofilin-1 work together to control cortical actin flow and leader bleb-based migration in confined cells.

Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments

This study shows that emerin regulates nuclear stiffness, which is essential for fast amoeboid migration of melanoma cells in confined environments.

A flexible network of Vimentin intermediate filaments promotes the migration of amoeboid cancer cells through confined environments

This study investigates the role of Vimentin intermediate filaments in amoeboid cancer cell migration through confined environments, finding that Vimentin bundling inhibits fast migration and proliferation.