Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus
S. F. Baker, H. Meistermann, M. Tzouros, A. Baker, S. Golling, J. S. Polster, M. P. Ledwith, A. Gitter, A. Augustin, H. Javanbakht, A. Mehle
The paper identifies a cryptic cytoplasmic isoform of MECR generated by alternative splicing that inhibits influenza virus replication by blocking viral RNP assembly.
bioRxiv · Nov 9, 2020Microbiology