Author

M. P. Ledwith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Mehle· 3 shared S. F. Baker· 2 shared A. Augustin· 1 shared A. B. Russell· 1 shared A. Baker· 1 shared A. da Silva Filipe· 1 shared A. Gitter· 1 shared C. B. Brooke· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

A. Mehle

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3 papers

Recent·Most cited

Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome

J. N. Ranum, M. P. Ledwith, F. G. Alnaji, M. Diefenbacher, R. Orton, E. Sloan, M. Guereca, E. M. Feltman, K. Smollett, A. da Silva Filipe, M. Conley, A. B. Russell, C. B. Brooke, E. Hutchinson, A. Mehle

The paper identifies cryptic proteins from deletion-containing viral genomes that inhibit influenza virus replication and expand its proteome.

bioRxiv · Dec 12, 2023Microbiology

Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus

S. F. Baker, H. Meistermann, M. Tzouros, A. Baker, S. Golling, J. S. Polster, M. P. Ledwith, A. Gitter, A. Augustin, H. Javanbakht, A. Mehle

The paper identifies a cryptic cytoplasmic isoform of MECR generated by alternative splicing that inhibits influenza virus replication by blocking viral RNP assembly.

bioRxiv · Nov 9, 2020Microbiology

Differential splicing of ANP32A in birds alters its ability to stimulate RNA synthesis by restricted influenza polymerase

S. F. Baker, M. P. Ledwith, A. Mehle

The paper shows that differential splicing of ANP32A in birds affects its ability to stimulate RNA synthesis by influenza polymerase, influencing viral replication and host range.

bioRxiv · Mar 2, 2018Microbiology