Evolutionary BiologybioRxiv
Repression precedes the stepwise evolution of a highly specific gene expression pattern
J. Pu, Z. Wang, H. Cong…·H. Chung
The paper traces the evolutionary origin of an enhancer that drives specific gene expression in Drosophila, showing that repressor sequences evolved before activator regions.
DOI 10.1016/j.celrep.2021.109896