H. Chung

Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women

This study identifies a distinct lipidome signature in Korean women with ovarian cancer, showing early-stage alterations and a predictive panel of 17 lipids with 85% accuracy.

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

Mutagenic-end joining results in smaller deletions in heterochromatin relative to euchromatin

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

Evolution of a fatty acyl-CoA elongase underlies desert adaptation in Drosophila

This study identifies a fatty acyl-CoA elongase gene, mElo, as crucial for desiccation resistance in Drosophila mojavensis through evolutionary changes enabling the synthesis of long-chain methylbranched cuticular hydrocarbons.

Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons

This study shows that variations in cuticular hydrocarbons, particularly methyl-branched CHCs, largely explain desiccation resistance differences among Drosophila species.

Seasonality but not photoperiodism affects susceptibility of the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) to pesticides

This study shows that seasonality, not photoperiodism, affects the susceptibility of spider mites to pesticides, with toxicity increasing in spring and summer and decreasing in winter.

Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice

This study shows that liposomal dexamethasone reduces mortality and inflammation in mice infected with A/H1N1 influenza by targeting monocyte/macrophages.

DrosoPhyla: genomic resources for drosophilid phylogeny and systematics

The paper develops genomic markers and constructs phylogenetic trees for 704 Drosophilidae species to clarify evolutionary relationships and resolve taxonomic uncertainties.

Do exercise-associated genes explain phenotypic variance in the three components of fitness? A Systematic review & Meta-analysis.

This study identifies 13 genes associated with fitness components and finds genetic factors explain 44-72% of phenotypic variance in response to exercise training.

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

Repression precedes the stepwise evolution of a highly specific gene expression pattern

The paper traces the evolutionary origin of an enhancer that drives specific gene expression in Drosophila, showing that repressor sequences evolved before activator regions.

High contrast probe cleavage detection on porous silicon biosensors via quantum dot labeled DNA probes

The paper demonstrates a high-contrast probe cleavage detection method using porous silicon biosensors and quantum dot-labeled DNA probes, achieving a significant signal shift for nucleic acid cleavage detection.

The Evolution of Insect Metallothioneins

This study reconstructs the evolutionary history of insect metallothioneins by developing a BLAST pipeline and analyzing phylogenetics and synteny, revealing lineage-specific duplications and a previously unknown MT variant.

Bilayer graphene oxide membranes for a wearable hemodialyzer

This paper presents a bilayer graphene oxide membrane with high permeability and selectivity for hemodialysis, showing improved performance over existing membranes.

ebony affects pigmentation divergence and cuticular hydrocarbons in Drosophila americana and D. novamexicana

This study tests the role of the ebony gene in pigmentation and cuticular hydrocarbon divergence between Drosophila americana and D. novamexicana using CRISPR/Cas9 mutants.

Altered Cell-Substrate Behavior on Microporous Membranes is a Result of Disruption and Grip

This study shows that microporous membranes alter cell-substrate behavior by disrupting cell-substrate interactions, promoting migration, and enhancing grip through pore edges.

Birth-and-death evolution of the fatty acyl-CoA reductase (FAR) gene family and diversification of cuticular hydrocarbon synthesis in Drosophila

The paper investigates the evolutionary dynamics of the FAR gene family in Drosophila, finding that genes involved in cuticular hydrocarbon synthesis show higher instability compared to those in essential fatty acid pathways.