Author

J. S. Welch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Miller· 2 shared D. C. Link· 2 shared D. H. Spencer· 2 shared J. E. Payton· 2 shared J. F. DiPersio· 2 shared R. S. Fulton· 2 shared S. E. Heath· 2 shared T. J. Ley· 2 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

C. Miller

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Author profile →

3 papers

Recent·Most cited

Immunosuppression and Outcomes in Acute Myeloid Leukemia

F. Ferraro, C. Miller, K. Christensen, N. M. Helton, M. O'Laughlin, C. C. Fronick, R. S. Fulton, J. Kohlschmidt, A.-K. Eisfeld, C. D. Bloomfield, S. M. Ramakrishnan, R. B. Day, L. D. Wartman, G. L. Uy, J. S. Welch, , T. J. Ley

This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.

bioRxiv · Sep 3, 2021 · PreprintCancer Biology

Bexarotene derivatives modify responses in acute myeloid leukemia

G. Hadwiger, O. di Martino, M. A. Ferris, A. Vu, T. E. Frederick, G. R. Bowman, P. Ruminski, C. Wagner, J. S. Welch

This study screens bexarotene derivatives to identify compounds with enhanced anti-leukemic activity in AML, finding that dual RARA/RXRA activity and structural modifications affect potency and metabolic stability.

bioRxiv · May 17, 2021 · PreprintCancer Biology

Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

E. R. Wilson, N. Helton, S. E. Heath, R. S. Fulton, C. Miller, J. E. Payton, J. S. Welch, M. Walter, P. Westervelt, J. F. DiPersio, D. C. Link, T. J. Ley, D. H. Spencer

This study identifies focal DNA hypermethylation in IDH-mutant AML samples and links it to TET2 and DNMT3A activity, with implications for AML pathogenesis.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology