Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis
N. Arthur, K. A. Christensen, K. Mannino, M. Ruzinova, A. Kumar, A. Gruszczynska, R. B. Day, P. Erdmann-Gilmore, Y. Mi, R. Sprung, C. R. York, D. H. Spencer, R. Townsend, S. M. Sykes, F. Ferraro
This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.
bioRxiv · Oct 22, 2023 · PreprintCancer Biology