Author

D. H. Spencer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Miller· 2 shared D. C. Link· 2 shared F. Ferraro· 2 shared J. E. Payton· 2 shared J. F. DiPersio· 2 shared J. S. Welch· 2 shared R. B. Day· 2 shared R. S. Fulton· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

C. Miller

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

N. Arthur, K. A. Christensen, K. Mannino, M. Ruzinova, A. Kumar, A. Gruszczynska, R. B. Day, P. Erdmann-Gilmore, Y. Mi, R. Sprung, C. R. York, D. H. Spencer, R. Townsend, S. M. Sykes, F. Ferraro

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.

bioRxiv · Oct 22, 2023 · PreprintCancer Biology

Immunosuppression and Outcomes in Acute Myeloid Leukemia

F. Ferraro, C. Miller, K. Christensen, N. M. Helton, M. O'Laughlin, C. C. Fronick, R. S. Fulton, J. Kohlschmidt, A.-K. Eisfeld, C. D. Bloomfield, S. M. Ramakrishnan, R. B. Day, L. D. Wartman, G. L. Uy, J. S. Welch, , T. J. Ley

This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.

bioRxiv · Sep 3, 2021 · PreprintCancer Biology

Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

E. R. Wilson, N. Helton, S. E. Heath, R. S. Fulton, C. Miller, J. E. Payton, J. S. Welch, M. Walter, P. Westervelt, J. F. DiPersio, D. C. Link, T. J. Ley, D. H. Spencer

This study identifies focal DNA hypermethylation in IDH-mutant AML samples and links it to TET2 and DNMT3A activity, with implications for AML pathogenesis.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology