Author

T. E. Frederick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. R. Bowman· 3 shared S. Singh· 2 shared U. L. Mallimadugula· 2 shared A. Vu· 1 shared C. R. Knoverek· 1 shared C. Wagner· 1 shared E. Rennella· 1 shared G. Hadwiger· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

G. R. Bowman

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Author profile →

3 papers

Recent·Most cited

Bexarotene derivatives modify responses in acute myeloid leukemia

G. Hadwiger, O. di Martino, M. A. Ferris, A. Vu, T. E. Frederick, G. R. Bowman, P. Ruminski, C. Wagner, J. S. Welch

This study screens bexarotene derivatives to identify compounds with enhanced anti-leukemic activity in AML, finding that dual RARA/RXRA activity and structural modifications affect potency and metabolic stability.

bioRxiv · May 17, 2021 · PreprintCancer Biology

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

C. R. Knoverek, U. L. Mallimadugula, S. Singh, E. Rennella, T. E. Frederick, T. Yuwen, S. Raavicharla, L. E. Kay, G. R. Bowman

The paper investigates how a cryptic pocket in β-lactamase, formed under the Ω-loop, enhances enzyme activity against penicillin, suggesting excited states can improve function.

bioRxiv · Apr 14, 2021Biophysics

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

M. A. Cruz, T. E. Frederick, U. L. Mallimadugula, S. Singh, N. Vithani, M. I. Zimmerman, J. R. Porter, K. E. Moeder, G. K. Amarasinghe, G. R. Bowman

This study identifies a cryptic pocket in Ebola VP35 that allosterically controls RNA binding, validated through simulations, experiments, and drug-like modifications.

bioRxiv · Feb 9, 2020Biochemistry