Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
C. G. Acevedo-Rocha, A. Li, L. D'Amore, S. Hoebenreich, J. Sanchis Martinez, P. Lubrano, M. Ferla, M. Garcia Borras, S. Osuna, M. T. Reetz
The paper quantifies cooperative mutational effects on multiple catalytic traits of a cytochrome P450 enzyme using computational methods and simulations, showing their modulation by long-range conformational dynamics.
bioRxiv · Apr 14, 2020Evolutionary Biology