Author

S. Osuna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 2 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:protein folding & dynamics· 4 Assay:protein structure· 4 Approach:deep learning· 2 Approach:experimental assay· 2 Approach:simulation· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. Calvo-Tusell· 2 shared C. G. Acevedo-Rocha· 2 shared F. Feixas· 2 shared A. Bar-Even· 1 shared A. J. Mulholland· 1 shared A. Li· 1 shared A. Romero-Rivera· 1 shared A. S. F. Oliveira· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

C. Calvo-Tusell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Origin Of Evolutionary Bifurcation In An Enzyme

C. M. Miton, E. C. Campbell, J. A. Kaczmarski, F. Feixas, A. Romero-Rivera, M. Sandhu, D. W. Anderson, N. Shatani, S. Osuna, C. J. Jackson, N. Tokuriki

The paper describes how two distinct enzymes evolved from a common ancestor through different mutational paths, leading to divergent molecular and phenotypic outcomes.

bioRxiv · Nov 25, 2023 · PreprintEvolutionary Biology

Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase

G. Casadevall, C. T. Pierce, B. Guan, J. Iglesias-Fernandez, H.-Y. Lim, L. R. Greenberg, M. E. Walsh, K. Shi, W. R. Gordon, H. Aihara, R. L. Evans, R. J. Kazlauskas, S. Osuna

The paper identifies eight mutations that convert a hydroxynitrile lyase into an efficient esterase by correcting structural differences using shortest path maps.

bioRxiv · Aug 23, 2023 · PreprintBioengineering

Decrypting the languages of allostery in membrane-bound K-Ras4B using four complementary in silico approaches

M. Castelli, F. Marchetti, S. Osuna, A. S. F. Oliveira, A. J. Mulholland, S. A. Serapian, G. Colombo

The paper uses four in silico methods to analyze allostery in K-Ras4B, showing how different 'languages' of allostery change with GTP perturbation.

bioRxiv · Jul 14, 2023Biochemistry

Unravelling the Graded Millisecond Allosteric Activation Mechanism of Imidazole Glycerol Phosphate Synthase

C. Calvo-Tusell, M. A. Maria-Solano, S. Osuna, F. Feixas

This paper uses computational methods to simulate the millisecond timescale allosteric activation mechanism of IGPS, revealing how effector binding lowers conformational barriers and enhances catalytic activity.

bioRxiv · Oct 21, 2021 · PreprintBiophysics

Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

C. G. Acevedo-Rocha, A. Li, L. D'Amore, S. Hoebenreich, J. Sanchis Martinez, P. Lubrano, M. Ferla, M. Garcia Borras, S. Osuna, M. T. Reetz

The paper quantifies cooperative mutational effects on multiple catalytic traits of a cytochrome P450 enzyme using computational methods and simulations, showing their modulation by long-range conformational dynamics.

bioRxiv · Apr 14, 2020Evolutionary Biology

In vivo selection for formate dehydrogenases with high efficiency and specificity towards NADP+

L. Calzadiaz Ramirez, C. Calvo-Tusell, G. M. M. Stoffel, S. Lindner, S. Osuna, T. J. Erb, M. Garcia-Borras, A. Bar-Even, C. G. Acevedo-Rocha

This study uses in vivo selection to engineer formate dehydrogenases with high efficiency and specificity for NADP+ regeneration.

bioRxiv · Apr 2, 2020 · PreprintBiochemistry