Author

J. Sher

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. J. Patel· 1 shared B. G. Nixon· 1 shared C. J. Lee· 1 shared C. R. Antonescu· 1 shared D. Zheng· 1 shared E. Giff· 1 shared E. Khurana· 1 shared E. W. P. Wong· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. J. Patel

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1 paper

Recent·Most cited

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

J. Yan, Y. Chen, A. J. Patel, S. Warda, B. G. Nixon, E. W. P. Wong, M. A. Miranda-Roman, C. J. Lee, N. Yang, Y. Wang, J. Sher, E. Giff, F. Tang, E. Khurana, S. Singer, , P. Chi

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

bioRxiv · May 27, 2022 · PreprintCancer Biology