D. Zheng

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma

This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.

Simulating Colloid Motion in Spinning Suspension: Internal Dynamics in Orbital Shaker

The paper presents a MATLAB simulation of colloid motion in orbital shakers to study particle dynamics in biomedical suspensions.

Trojan horse virus delivering CRISPR-AsCas12f1 controls plant bacterial wilt caused by Ralstonia solanacearum

This paper develops an engineered filamentous phage that delivers CRISPR-AsCas12f1 to target Ralstonia solanacearum's virulence gene hrpB, effectively controlling bacterial wilt in tobacco.

Addressing preferred orientation in single-particle cryo-EM through AI-generated auxiliary particles.

This paper introduces cryoPROS, an AI method to address preferred orientation in cryo-EM, improving resolution without special experimental techniques.

Brd4-Nutm1 fusion gene initiates NUT carcinoma in vivo

This study creates a genetically engineered mouse model of NUT carcinoma by inducing the Brd4::Nutm1 fusion gene, showing it can initiate aggressive tumors with features similar to human NC.

Targeted inhibition of SCF-SKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma

This study shows that inhibiting SKP2 in osteosarcoma reduces tumor growth and improves survival, suggesting it as a potential therapeutic target.

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

This study shows SKP2 knockout in osteosarcoma mouse models increases immune infiltration and correlates with improved patient survival.

A single amino acid substitution in MdLAZY1A dominantly impairs shoot gravitropism in Malus

This study identifies a single amino acid substitution in MdLAZY1A that causes weeping growth in apple by impairing gravitropism.

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

This study identifies unique features of long-lived plasma cells (LLPCs), including reduced motility, clustering, and specific surface markers, and shows that CXCR4 is critical for their survival and antibody production.

Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics

The paper introduces an ex vivo intestinal permeability assay (X-IPA) to quantify gut permeability dynamics and shows that specific microbes and metabolites induce rapid, dose-dependent increases in permeability.

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

Functional Contribution of Cancer-Associated Fibroblasts in Glioblastoma

This study identifies and characterizes cancer-associated fibroblasts (CAFs) in glioblastoma using single-cell RNA sequencing and spatial transcriptomics, revealing their functional roles in tumor progression and microenvironment interactions.

Keystone species determine the productivity of synthetic microbial biofilm communities

The paper identifies keystone species in synthetic microbial biofilm communities that influence their productivity through metabolic facilitation or competition.

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

Chasing the metabolism of novel syntrophic acetate-oxidizing bacteria in thermophilic methanogenic chemostats

This study identifies and characterizes novel syntrophic acetate-oxidizing bacteria in thermophilic methanogenic chemostats, revealing their metabolic pathways and interactions with methanogenic partners.

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

Bayesian metamodeling of complex biological systems across varying representations

This paper introduces Bayesian metamodeling to integrate diverse models of biological systems, demonstrating its application to glucose-stimulated insulin secretion in pancreatic β-cells.

Butyryl/Caproyl-CoA:Acetate CoA-Transferase: Cloning, Expression and Characterization of the Key Enzyme Involved in Medium-Chain Fatty Acid Biosynthesis

This study identifies and characterizes two CoAT enzymes from bacteria, showing CPB6-CoAT can catalyze both butyrate and caproate synthesis, while BEY8-CoAT only catalyzes butyrate synthesis.

Methylation of KRAS at lysine 182 and 184 by SETD7 promotes KRAS degradation

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

Regulation of intracellular signaling and neuron function by Bardet-Biedl Syndrome proteins in patient-specific iPSC-derived neurons

This study investigates how BBS mutations affect neuron function and signaling in iPSC-derived neurons, identifying impaired ciliary function and signaling pathways related to energy homeostasis.

YY1 cistrome analysis uncovers an essential requirement of the YY1:BRD4-PFKP regulatory axis for promoting tumorigenesis of castration-resistant prostate cancer

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

This study identifies GREB1 as a driver of antiandrogen resistance in prostate cancer by amplifying androgen receptor output through enhanced DNA binding and p300 recruitment.