Cancer BiologybioRxiv
Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment
A. M. Fuller, H. C. Pruitt, Y. Liu…·T. S. K. Eisinger-Mathason
This study identifies YAP1-driven collagen VI deposition in sarcoma as a mechanism suppressing CD8+ T cell function through ECM remodeling and autophagy inhibition.