Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in Strongyloides stercoralis
Z. Wang, M. C. Cheong, J. Tsien, H. Deng, T. Qin, J. D. C. Stoltzfus, T. G. Jaleta, X. Li, J. B. Lok, S. A. Kliewer, D. J. Mangelsdorf
This study identifies {Delta}7-DA as the endogenous ligand for Ss-DAF-12 in Strongyloides stercoralis and shows its potential as a therapeutic target when combined with ivermectin.
bioRxiv · Sep 7, 2021Pharmacology & Toxicology