Author

J. Urrutia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Aguado· 2 shared A. Muguruza-Montero· 2 shared A. Villarroel· 2 shared C. Malo· 2 shared E. Nunez· 2 shared A. Bergara· 1 shared A. Leonardo· 1 shared C. Domene· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

A. Aguado

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2 papers

Recent·Most cited

Redox regulation of Kv7 channels through EF3 hand of calmodulin

E. Nunez, F. Jones, A. Muguruza-Montero, J. Urrutia, A. Aguado, C. Malo, C. Domene, G. Bernardo-Seisdedos, O. Millet, N. Gamper, A. Villarroel

This study shows that EF3 hand of calmodulin mediates redox regulation of Kv7 channels by translating Ca2+ signals and reversing FRET signals in response to oxidation.

eLife · Feb 20, 2023Peer-reviewedCell Biology

AN EPILEPSY-CAUSING MUTATION LEADS TO CO-TRANSLATIONAL MISFOLDING

J. Urrutia, A. Aguado, C. Gomis-Perez, A. Muguruza-Montero, O. R. Ballesteros, J. Zhang, E. Nunez, C. Malo, H. J. Chung, A. Leonardo, A. Bergara, A. Villarroel

The paper shows that the W344R mutation in Kv7.2 channels causes co-translational misfolding, impairing CaM binding and leading to non-functional ion channels.

bioRxiv · Nov 25, 2020Biophysics