Author

J. Velcicky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

E. J. Sanderlin· 2 shared L. V. Yang· 2 shared P. Loetscher· 2 shared E. A. Krewson· 1 shared M. A. Marie· 1 shared M. Marie· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

E. J. Sanderlin

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2 papers

Recent·Most cited

The proton-sensing GPR4 receptor regulates paracellular gap formation and permeability of vascular endothelial cells

E. A. Krewson, E. J. Sanderlin, M. A. Marie, J. Velcicky, P. Loetscher, L. V. Yang

This study shows that GPR4 activation in endothelial cells under acidic conditions increases paracellular gap formation and permeability, mediated by G12/13 signaling, and suggests GPR4 as a therapeutic target for inflammation and edema.

bioRxiv · Apr 6, 2019Cell Biology

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model

E. J. Sanderlin, M. Marie, J. Velcicky, P. Loetscher, L. V. Yang

This study shows that inhibiting GPR4 with antagonist 13 reduces intestinal inflammation in a DSS-induced colitis mouse model by improving clinical and histopathological outcomes.

bioRxiv · Jan 29, 2019Pharmacology & Toxicology