Dscam homophilic specificity is generated by high order cis-multimers coupled with trans self-binding of variable Ig1 in Chelicerata
F. Zhou, G. Cao, S. Dai, G. Li, H. Li, Z. Ding, S. Hou, B. Xu, W. You, F. Shi, X. Yang, J. Yongfeng
The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.
bioRxiv · Dec 15, 2019 · PreprintBiochemistry