Author

J.-F. Brazeau

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Seitova· 1 shared C. Chaudhry· 1 shared D. Barsyte-Lovejoy· 1 shared D. Duda· 1 shared G. L. Righetto· 1 shared H. Zeng· 1 shared L. Halabelian· 1 shared M. Szewczyk· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Seitova

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1 paper

Recent·Most cited

Probing the DCAF12 interactions with MAGEA3 and CCT5 C-terminal degrons

G. L. Righetto, Y. Yin, V. Vu, D. Duda, M. Szewczyk, H. Zeng, Y. Li, P. Loppnau, T. Mei, Y.-Y. Li, A. Seitova, J.-F. Brazeau, D. Barsyte-Lovejoy, V. Santhakumar, C. Chaudhry, L. Halabelian

This study characterizes DCAF12 interactions with MAGEA3 and CCT5 degrons using biophysical assays and cryo-EM, revealing key residues for degron recognition and informing PROTAC design.

bioRxiv · Aug 15, 2023 · PreprintBiochemistry