Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
C. H. Arrowsmith, S. Ackloo, F. Li, M. Szewczyk, A. Seitova, P. Loppnau, H. Zeng, S. Ahmad, S. Beldar, A. Bolotokova, I. Chau, S. Dehghani-Tafti, A. Dong, P. Ghiabi, E. Gibson, , Arnautova
The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.
bioRxiv · Mar 3, 2024Biochemistry
G. L. Righetto, Y. Yin, V. Vu, D. Duda, M. Szewczyk, H. Zeng, Y. Li, P. Loppnau, T. Mei, Y.-Y. Li, A. Seitova, J.-F. Brazeau, D. Barsyte-Lovejoy, V. Santhakumar, C. Chaudhry, L. Halabelian
This study characterizes DCAF12 interactions with MAGEA3 and CCT5 degrons using biophysical assays and cryo-EM, revealing key residues for degron recognition and informing PROTAC design.
bioRxiv · Aug 15, 2023 · PreprintBiochemistry
S. Kimani, S. Perveen, M. Szewczyk, H. Zeng, A. Dong, F. Li, P. Ghiabi, Y. Li, I. Chau, C. Arrowsmith, D. Barsyte-Lovejoy, V. Santhakumar, M. Vedadi, L. Halabelian
The paper investigates how a small-molecule inhibitor binds to and inactivates Cbl-b, revealing a structural mechanism that locks the protein in an inactive conformation.
bioRxiv · May 5, 2023 · PreprintImmunology
S. Perveen, C. A. Zepeda-Velazquez, D. McLeod, R. Marcellus, M. Mohammed, M. Abbey, D. Ensan, D. Panagopoulos, V. Trush, E. Gibson, A. Dong, L. Halabelian, G. Poda, J. Owen, A. Aman, , M. Vedadi
This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.
bioRxiv · Jan 5, 2022 · PreprintBiochemistry
B. J. Fraser, S. Beldar, A. Seitova, A. Hutchinson, D. Mannar, Y. Li, D. Kwon, R. Tan, R. P. Wilson, K. Leopold, S. Subramaniam, L. Halabelian, C. H. Arrowsmith, F. Benard
This study characterizes the structure and function of TMPRSS2, a protease involved in SARS-CoV-2 activation, and identifies features for developing selective inhibitors.
bioRxiv · Jun 23, 2021Biochemistry
Y. Shen, F. Li, M. Szewczyk, L. Halabelian, I. Chau, M. S. Eram, C. Dela Sena, K.-S. Park, F. Meng, H. Chen, H. Zeng, D. McLeod, C. A. Zepeda-Velazquez, R. M. Campbell, M. M. Mader, , J. Jin
This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.
bioRxiv · Dec 4, 2020 · PreprintBiochemistry
Z. Zhu, Z. Han, L. Halabelian, X. Yang, J. Ding, N. Zhang, L. Ngo, J. Song, H. Zeng, M. He, Y. Zhao, C. H. Arrowsmith, M. Luo, M. G. Bartlett, Y. G. Zheng
The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.
bioRxiv · Aug 31, 2020Biochemistry
G. L. Righetto, D. Sriranganadane, L. Halabelian, C. Gottschald Chiodi, J. Elkins, K. B. Massirer, O. Gileadi, M. Menossi, R. Counago
This study investigates the role of SnRK2-box and ABA-box domains in sugarcane SnRK2s auto-activation and activity, revealing distinct regulatory mechanisms compared to Arabidopsis.
bioRxiv · Mar 26, 2019Plant Biology
L. Halabelian, M. Ravichandran, Y. Li, H. Zheng, L. Aravind, A. Rao, C. H. Arrowsmith
This study reports crystal structures of the HMCES SRAP domain bound to DNA-damage substrates, revealing how HMCES recognizes and binds different DNA structures for crosslinking.
bioRxiv · Jan 13, 2019Biochemistry