Author

J.-J. LAI

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Immunology· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Zeng· 1 shared J. Zhu· 1 shared K. Rock· 1 shared L. A. A. Orellano· 1 shared M. Bogyo· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

C. Zeng

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1 paper

Recent·Most cited

A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation, and gout arthritis

L. A. A. Orellano, C. Zeng, J. Zhu, M. Bogyo, K. Rock, J.-J. LAI

This study shows that broad-spectrum cathepsin inhibitors block crystal-induced inflammation and gout arthritis by inhibiting both inflammasome-dependent and -independent pathways that generate IL-1β.

bioRxiv · Jul 1, 2024Immunology