Host prion protein expression levels impact prion tropism for the spleen
V. Beringue, P. TIXADOR, O. ANDREOLETTI, F. REINE, J. Castille, T.-L. Lai, A. Le Dur, A. Laisne, L. HERZOG, B. PASSET, H. Rezaei, J.-L. VILOTTE, H. LAUDE
This study shows that prion substrain tropism for the spleen is influenced by PrPC expression levels, with low-expressing substrains dominating in the spleen while high-expressing substrains struggle to replicate there.
bioRxiv · Dec 17, 2019Pathology