Author

L. Herzog

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Organism:rat· 2

Frequent Co-Authors

F. Reine· 4 shared H. Rezaei· 4 shared V. Beringue· 4 shared A. Igel· 2 shared H. Klute· 2 shared M. Moudjou· 2 shared O. Andreoletti· 2 shared A. Igel-Egalon· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

F. Reine

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

A. Knyazeva, S. Li, D. Corkery, K. Shankar, L. Herzog, X. Zhang, B. Singh, G. Niggemeyer, D. Grill, J. Gilthorpe, M. Gaetani, L.-A. Carlson, H. Waldmann, Y. Wu

This study inhibits the IST1-CHMP1B interaction in ESCRT-III, impairing endosomal recycling and inducing unconventional LC3 lipidation at stalled endosomes.

bioRxiv · Aug 28, 2023Cell Biology

The smallest infectious substructure encoding the prion strain structural determinant revealed by spontaneous dissociation of misfolded prion protein assemblies

J. Bohl, M. Moudjou, L. Herzog, F. Reine, F. Sailer, H. Klute, F. Halgand, G. Vand der Rest, Y. Boulard, A. Igel, V. Beringue, H. Rezaei

The paper identifies small infectious prion oligomers that encode the strain structural determinant, showing prion infectivity and SSD are not exclusive to amyloid fibrils.

bioRxiv · Mar 21, 2023Biochemistry

Pathogenicity, strain properties and interspecies transmission capacity of pure recombinant prion protein assemblies

H. Rezaei, D. Martin, L. Herzog, F. Reine, N. Aron, A. Igel, H. Klute, S. Youssafi, J.-B. Moog, P. Sibille, O. Andreoletti, J. Torrent, V. Beringue

This paper generates prions from recombinant prion protein assemblies with distinct biological properties and shows their transmissibility to mice, revealing structural features critical for prion pathobiology.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology

Host prion protein expression levels impact prion tropism for the spleen

V. Beringue, P. TIXADOR, O. ANDREOLETTI, F. REINE, J. Castille, T.-L. Lai, A. Le Dur, A. Laisne, L. HERZOG, B. PASSET, H. Rezaei, J.-L. VILOTTE, H. LAUDE

This study shows that prion substrain tropism for the spleen is influenced by PrPC expression levels, with low-expressing substrains dominating in the spleen while high-expressing substrains struggle to replicate there.

bioRxiv · Dec 17, 2019Pathology

Quaternary structural convergence and structural diversification of prion assemblies at the early replication stage

A. Igel-Egalon, F. Lafferriere, M. Moudjou, M. Merzach, T. Knapple, L. Herzog, F. Reine, M. Doumic, H. Rezaei, V. Beringue

This study investigates the structural convergence and diversification of PrPSc assemblies during prion replication, revealing a secondary templating pathway that explains structural diversification.

bioRxiv · Mar 20, 2019 · PreprintBiochemistry