Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro
G. Lee, S. Budhathoki, G.-Y. Lee, K.-j. Oh, Y. K. Ham, Y. J. Kim, Y. R. Lim, P. T. Hoang, Y. Lee, S.-W. Lim, J.-M. Kim, S. Cho, T.-H. Kim, J.-W. Song, S. Lee, W.-K. Kim
This study demonstrates that 3D8 scFv inhibits replication of SARS-CoV-2, HCoV-OC43, and PEDV in vitro through nucleic acid hydrolysis.
bioRxiv · Nov 25, 2020 · PreprintMicrobiology