Y. J. Kim

Optogenetic dissection of transcriptional repression in a multicellular organism

This study uses optogenetics and mathematical modeling to show that the zinc-finger repressor Knirps rapidly and memorylessly represses gene expression by reducing transcriptional burst frequency.

Homeostatic Dysregulation of Systemic CD8+ T Cell Compartment in Lung Cancer Patients

The paper shows cancer causes systemic CD8+ T cell homeostatic dysregulation, leading to uncontrolled differentiation and poor immune checkpoint inhibitor response.

Magnetoelectric Nanodiscs Enable Wireless Transgene-Free Neuromodulation

This study develops magnetoelectric nanodiscs (MENDs) for wireless, transgene-free neuromodulation, showing they can control reward behavior in mice through magnetic field stimulation.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS-mutated chronic myelomonocytic leukemia

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Newly discovered alleles of the tomato antiflorigen gene SELF PRUNING provide a range of plant compactness and yield

The paper identifies new alleles of the tomato SELF PRUNING gene that alter plant compactness and yield, with sp-5732 increasing yield by up to 42%.

The addition of FAIMS Increases Targeted Proteomics Sensitivity from FFPE Tumor Biopsies

This paper demonstrates that combining FAIMS with PRM enhances targeted proteomics sensitivity in FFPE tumor biopsies, particularly for HER2, EGFR, cMET, and KRAS.

Spermidine dampens inflammation by directly inhibiting Th17 cytokine production through a PRDX1 associated antioxidant pathway

This study shows spermidine directly inhibits Th17 cytokine production via PRDX1-dependent antioxidant activity, reducing lung inflammation in mouse models.

Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

The paper uses thermodynamic models to show that higher-order cooperativity between transcription factors drives transcriptional repression in a synthetic enhancer.

Role of Gasdermins in the Biogenesis of Apoptotic Cell-Derived Exosomes

This study identifies gasdermin-mediated mechanisms in apoptotic exosome biogenesis and shows their role in tumor-induced inflammation.

Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

The paper presents a cryo-EM structure of the yeast THO*Sub2 complex and shows its interaction with the SR-like protein Gbp2, suggesting a role in mRNP maturation.

Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro

This study demonstrates that 3D8 scFv inhibits replication of SARS-CoV-2, HCoV-OC43, and PEDV in vitro through nucleic acid hydrolysis.

Real-time single-cell characterizationof the eukaryotic transcription cyclereveals correlations between RNAinitiation, elongation, and cleavage

This study uses Bayesian inference to analyze real-time single-cell transcription dynamics in fruit flies, revealing correlations between RNA initiation, elongation, and cleavage.

COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis

The paper identifies upregulated TLR4-mediated inflammatory signaling in COVID-19 patients, linking it to pathological inflammation and suggesting TLR4 as a therapeutic target.

Targeting cardiac myocyte Na+ pump function with β3 adrenergic agonist in rabbits and patients with severe congestive heart failure

This study shows that β3 adrenergic agonists improve cardiac function in rabbits and patients with severe heart failure by enhancing Na+-K+ pump activity and reducing congestion.

Pinealectomy increases thermogenesis and decreases lipogenesis

This study shows that pinealectomy in rats increases thermogenesis in brown adipose tissue and decreases lipogenesis in white adipose tissue and the liver.

Defining the Subcellular Distribution and Metabolic Channeling of Phosphatidylinositol

The paper defines the subcellular distribution and metabolic channeling of phosphatidylinositol using a bacterial enzyme to study its dynamics in intact cells.

Bacterial clearance enhanced by α2, 3- and α2, 6-sialyllactose via receptor-mediated endocytosis and phagocytosis

This study shows that sialyllactose enhances bacterial clearance in mice and human macrophages through receptor-mediated endocytosis, phagocytosis, and Rac1-mediated reactive oxygen species production.