Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS-TBK1 Activation .
L.-F. Lu, Z.-C. Li, C. Zhang, X.-y. Zhou, Y. Zhou, J.-Y. Jiang, D.-d. Chen, S. Li, Y.-A. Zhang
This paper identifies how GCRV proteins interact with fish RLR factors to suppress MAVS-TBK1 signaling and reduce IFN expression, revealing a unique fish virus evasion mechanism.
bioRxiv · Oct 3, 2019Immunology