Discovery of a novel chemotype targeting Mycobacterium tuberculosis cytochrome bd through rapid screening and structural elucidation
Tijn T. van der Velden, Asad Halimi, J.P.V. Pols, Wing-Sam Lam, Stephan M. Hacker, Lars J. C. Jeuken
This paper identifies a novel compound targeting Mycobacterium tuberculosis cytochrome bd through in vitro screening and structural analysis, showing growth inhibition and competitive inhibition at the quinol-binding site.
bioRxiv · May 22, 2026 · PreprintBiochemistry