Stephan M. Hacker

This study identifies natural product-derived azaphilones as selective scaffolds for covalent lysine liganding in live cells, revealing bacterial chemotaxis as a major target pathway.

This paper identifies a novel compound targeting Mycobacterium tuberculosis cytochrome bd through in vitro screening and structural analysis, showing growth inhibition and competitive inhibition at the quinol-binding site.

This study uses BONCAT to identify the proteome of S. aureus persisters under antibiotic stress, revealing upregulated pathways and downregulated processes involved in survival.