Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses
Yan‐Jiun Lee, Jianjun Li, Cecilia Sobieski, Sophie H Young, Jacek Stupak, Evgeny V. VINOGRADOV, Hongyan Zhou, Wangxue Chen, Peter Weigele, Danielle L. Peters
The paper identifies 5-hydroxycytosine (5hoC) as a precursor for glycosylated cytosine derivatives in viral DNA, revealing a novel mechanism for evading host defenses.
Nucleic Acids Research · Jun 16, 2026Peer-reviewedMicrobiology