Yan‐Jiun Lee

The paper identifies 5-hydroxycytosine (5hoC) as a precursor for glycosylated cytosine derivatives in viral DNA, revealing a novel mechanism for evading host defenses.

The paper identifies 5mC-selective deaminases and demonstrates their use in ultra-sensitive methylome sequencing at single-base resolution.

The paper identifies a methylome-derived m6-dAMP trigger that forms an immune filament in E. coli to deplete dNTPs and abort phage infection.

The paper introduces KlebPhaCol, a resource containing 53 phages and 74 Klebsiella isolates, including a novel gut phage order, to advance understanding of Klebsiella-phage interactions.

The paper identifies DNA glycosylases as antiviral effectors in bacteria, showing their conserved structure and role in defending against phages with modified nucleobases.

The paper identifies ENDPaCF1, a novel defense system in Pseudomonas aeruginosa, which targets hypermodified phage DNA through an endonuclease domain fused to an inactive Endonuclease III, revealing its role in antiphage immunity.

This study examines broad-host-range Vibrio phages, identifying genetic features and ecological trade-offs that influence their host range and environmental distribution.

The paper identifies four new 7-deazaguanine derivatives in phages and characterizes enzymes involved in their biosynthesis and insertion into DNA.