Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins
Ting Zhou, Huan Min Yang, Carmel Rebecca Assa, Elise DeRoo, Jack Bontekoe, Brian M. Burkel, Suzanne M. Ponik, Hong S. Lu, Alan Daugherty, Bo Liu
This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.
bioRxiv · Jul 30, 2024 · PreprintPathology