Suzanne M. Ponik

This paper presents a multi-omics platform for simultaneous lipid, metabolite, and protein analysis of sEVs using sequential extraction and mass spectrometry, achieving deep and reproducible characterization with 10 million sEVs.

This study shows that exosomes initiate fibronectin assembly in vitro and in vivo, reducing tumor growth and fibrosis.

This study shows that high collagen content in tumors limits bacterial penetration and reduces the efficacy of Salmonella-based cancer therapy.

This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.

This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.