Tie2-Dependent Mechanisms Promote Leptomeningeal Collateral Remodeling and Reperfusion Following Stroke
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu‐Hui Lin, Hehuang Xie, John B. Matson, Michelle Hedrick Theus
This study shows that Tie2 activation with Vasculotide enhances leptomeningeal collateral remodeling and reperfusion after stroke, while EphA4 inhibition mimics these effects, highlighting their opposing roles in vascular adaptation.
bioRxiv · Feb 28, 2025 · PreprintNeuroscience