Author

Michelle Hedrick Theus

Virginia TechORCID 0000-0001-6485-2104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alexandra M. KalossiD· 2 shared Hehuang XieiD· 2 shared Andrew Willison· 1 shared Benjamin Conacher· 1 shared Caroline de JageriD· 1 shared Eman SolimaniD· 1 shared Erik A. Johnson· 1 shared Erwin Kristobal Gudenschwager BassoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersNeuroscience

Alexandra M. KalossORCID

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4 papers

Recent·Most cited

Meningeal vascular Aβ deposition associates with cerebral hypoperfusion and compensatory collateral remodeling

Alexandra M. Kaloss, Jack L. Browning, Jiangtao Li, Yuhang Pan, Sachi Watsen, Harald W. Sontheimer, Michelle Hedrick Theus, Michelle Lynne Olsen

This study shows that Aβ deposition in meningeal arteries correlates with reduced cerebral blood flow and collateral vessel remodeling in a mouse model of AD, with sex differences in Aβ burden.

Alzheimer s Research & Therapy · Nov 13, 2025Peer-reviewedNeuroscience

Tie2-Dependent Mechanisms Promote Leptomeningeal Collateral Remodeling and Reperfusion Following Stroke

Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu‐Hui Lin, Hehuang Xie, John B. Matson, Michelle Hedrick Theus

This study shows that Tie2 activation with Vasculotide enhances leptomeningeal collateral remodeling and reperfusion after stroke, while EphA4 inhibition mimics these effects, highlighting their opposing roles in vascular adaptation.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience

Machine Learning Identifies Genes Linked to Neurological Disorders Induced by Equine Encephalitis viruses (EEV), Traumatic Brain Injuries (TBI), and Organophosphorus nerve agents (OPNA)

Liduo Yin, Morgen VanderGiessen, V. Vinoth Kumar, Benjamin Conacher, Po-Chien Haku Chao, Michelle Hedrick Theus, Erik A. Johnson, Kylene Kehn‐Hall, Xiaowei Wu, Hehuang Xie

The paper uses machine learning to identify genes associated with neurological disorders from TBI, EEV, and OPNA by integrating transcriptomic data and analyzing gene expression patterns.

bioRxiv · Nov 21, 2024 · PreprintNeuroscience

Skull bone marrow-derived immune cells infiltrate the damaged cortex and exhibit anti-inflammatory properties

Eman Soliman, Erwin Kristobal Gudenschwager Basso, Jing Ju, Andrew Willison, Michelle Hedrick Theus

This study shows skull bone marrow-derived immune cells infiltrate the injured brain, exhibit anti-inflammatory properties, and differ from blood-derived macrophages in their phenotype and distribution.

bioRxiv · Jun 21, 2024 · PreprintNeuroscience